At the end of 2007, the cumulative number of known HIV-positive Singaporeans was 3,224, up from 2,075 in 2003. In 2006, 357 newly diagnosed HIV infection cases were recorded compared to 317 in 2005. The prevalence of known HIV cases in the resident population (aged 15 and above) was 0.07% and for pregnant women 0.05%. The male population is most affected by the virus.

Out of 3,224 cumulative HIV cases, 89% were among men, 69% acquired HIV through heterosexual transmission, and 24% contracted HIV through homosexual or bisexual contact. In the same period, only 2% of all HIV infection cases occurred through injecting drug use.

In the first six months of 2007, 76% of all diagnosed HIV cases were detected during medical care and 12% through voluntary HIV screening.

At risk groups mainly include female sex workers and men having unprotected sex with multiple partners, including men who have sex with men.